G-quadruplexes Catalyze Protein Folding by Reshaping the Energetic Landscape

Chemistry, Physical Chemistry, Medicine, Life Sciences, Biochemistry,
protein folding   G-quadruplex   energy landscape   molecular chaperone   nucleic acid  

G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...

Early Mechanisms of Left-Right Symmetry Breaking in Amniote Gastrulation

Medicine, Life Sciences, Cell Biology, Biophysics,
left-right symmetry   gastrulation   cellular flows   biophysics   particle image velocimetry  

Early Origin of Left-Right Asymmetry in Embryonic Development Academic Background Bilateral symmetry is a widely prevalent body structure feature in the animal kingdom. However, while vertebrates exhibit bilateral symmetry externally, their internal organs display left-right (LR) asymmetry. This asymmetry plays a crucial role during embryonic devel...

Contextual Neural Dynamics during Time Perception in the Primate Ventral Premotor Cortex

Medicine, Neurology, Life Sciences, Cell Biology, Biophysics,
time perception   ventral premotor cortex   neuronal responses   task-dependence   time intervals  

Neural Dynamics of Time Perception in the Ventral Premotor Cortex Academic Background Time perception is one of the central questions in neuroscience, particularly how the brain encodes time information as cognitive demands change. Time can be categorized as “long” or “short,” or it can be precisely represented as continuous intervals. The ventral ...

Active Vision in Freely Moving Marmosets Using Head-Mounted Eye Tracking

Medicine, Neurology, Ophthalmology, Life Sciences, Bioengineering,
vision   marmosets   eye-tracking   head-mounted devices   natural behavior   vestibulo-ocular reflex   gaze stabilization  

Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...

Evidence for Domain-General Arousal from Semantic and Neuroimaging Meta-Analyses Reconciles Opposing Views on Arousal

Medicine, Anesthesiology, Neurology, Life Sciences, Biophysics,
arousal   semantic analysis   neuroimaging   meta-analysis   natural language processing  

Neuroscientific Research Report on “Domain-General Arousal” Academic Background Arousal is a core concept in neuroscience, referring to fluctuations in brain and body states that underpin motivated behavior. Despite the widespread use of the term “arousal,” its definition has remained ambiguous, with differing interpretations in various textbooks. ...

Fixational Eye Movements as Active Sensation for High Visual Acuity

Medicine, Neurology, Ophthalmology, Life Sciences, Biophysics,
fixational eye movements   visual acuity   retinal coding   Bayesian inference   adaptive optics  

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...