Breakthrough Study on Consistent Self-Organized Formation of Hyaline Cartilage in hiPSC-Derived Multi-Tissue Organoids I. Academic Background 1.1 The Medical Challenge of Cartilage Injury Cartilage is an important connective tissue within human joints, with hyaline cartilage especially covering joint surfaces and playing a core role in smooth movem...

Background Introduction Diabetes, especially type 1 diabetes (T1D), is a chronic autoimmune disease characterized by the persistent destruction of pancreatic β cells by the immune system, resulting in the loss of the ability to regulate blood glucose. Patients with type 1 diabetes typically require lifelong insulin injections; however, long-term in...

I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...

Research Background and Academic Significance Olfaction is one of the most important ways for humans to sense the external environment, fundamentally relying on olfactory sensory neurons (OSNs) in the olfactory epithelium (OE). These neurons possess the ability to regenerate throughout life, primarily due to the presence of local basal stem cell po...

Academic Background and Research Motivation In recent years, the field of stem cell and regenerative medicine has developed rapidly. Due to their multipotency and self-renewal capacity, stem cells have become a vital cell source for tissue repair and regeneration. Among the many types of stem cells, Mesenchymal Stem Cells (MSCs) have drawn consider...