Fibroblast Activation Protein-α Interacts with CXCL12 to Inactivate Canonical Wnt Signaling and Regulate Osteoblast Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
fibroblast activation protein-α   CXCL12   Wnt/β-catenin pathway   osteoblast differentiation   adipocyte differentiation   osteoporosis   mesenchymal progenitor cells  

Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...

Neuropeptide Substance P Modulates Stem Cell Fate to Promote Wound Healing and Epidermal Stratification via Asymmetric Divisions

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Substance P   stem cell fate   wound healing   epidermal stratification   asymmetric division   sensory innervation   re-epithelialization  

Neuropeptide Substance P Regulates Stem Cell Division to Promote Wound Healing and Epidermal Stratification: An In-depth Interpretation of the Latest Study by Khalifa et al. Research Background and Scientific Questions Wound healing following skin injury has long been a central focus in both clinical and basic medical sciences. With aging, diabetes...

E3 Ligase TRIM63 Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells by Catalyzing K27-Linked Cysteine Ubiquitination of MYH11

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
TRIM63   mesenchymal stem cells   chondrogenic differentiation   ubiquitination   MYH11   cartilage repair   osteoarthritis  

Research Progress on the Role of E3 Ubiquitin Ligase TRIM63 in Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells — An Interpretation of the Paper “E3 ligase TRIM63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of MYH11” 1. Academic Background and Research Motivati...

Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...

Overexpression of ZIC1 Transcription Factor in Segmental Bone Defects Promotes Brown Adipogenic and Osteogenic Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
ZIC1 transcription factor   osteogenic differentiation   brown adipogenesis   segmental bone defect   stem cells   human adipose progenitor cells   hedgehog signaling  

1. Academic Background and Research Significance Human bone tissue possesses a certain degree of self-healing capability. However, after suffering from severe trauma, tumor resection, infection, or congenital deformity, leading to large-volume bone defects, this regenerative ability becomes limited. The so-called “critical size bone defect” refers ...