METTL3 Promotes Osteogenesis by Regulating N6-Methyladenosine-Dependent Primary Processing of hsa-mir-4526

Medicine, Orthopedics, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
METTL3   osteogenesis   N6-methyladenosine   miRNA processing   hsa-mir-4526   adipose stem cells   bone repair  

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...

PDGFR Marks Distinct Mesenchymal and Pericyte Populations Within the Periosteum With Overlapping Cellular Features

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
periosteum   PDGFRβ   mesenchymal progenitor cells   pericytes   bone regeneration   single-cell RNA sequencing  

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...

Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
antisense oligonucleotide   splicing mutation   hotspot exon   RNA splicing   actionable genes   gene mutation   therapeutic strategy  

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...

Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   PKD2   ion channels   cryo-EM   channel dysfunction   protein assembly  

Molecular Mechanism Analysis of ADPKD Pathogenic Variants in Ion Channels – In-depth Interpretation of PNAS 2025 Latest Original Research I. Academic Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders worldwide, affecting millions of individuals. The pat...

Mechanistic Analysis of Channel Dysfunction Caused by Diverse Pathogenic Polycystin Pore Helix Variants

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   channelopathy   ion channel   primary cilia   structure   drug development  

I. Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic hereditary kidney disease that affects millions of people worldwide. ADPKD is primarily caused by mutations in the renal polycystin family (especially the PKD1 and PKD2 genes), which encode channel subunits pivotal for ion c...