Unlocking a New Mechanism for the Regulation of Neurotransmitter Release: A Review of Munc13-1’s Novel Autoinhibitory Structure and Its Calcium-Modulated Role I. Academic Background and Research Motivation Signal transmission between neurons relies on chemical synapses, with precise neurotransmitter release from presynaptic terminals via synaptic e...

Academic Background In recent years, the role of immune signaling pathways in nervous system homeostasis has garnered increasing attention. Traditionally, the inflammasome, a core complex of innate immunity, was thought to activate only during infection or tissue damage, participating in pathological processes through caspase-1-mediated pyroptosis ...

Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...

Academic Background G protein-coupled receptors (GPCRs) are the most abundant family of cell surface receptors in the human body and are also the most common targets of FDA-approved drugs. GPCRs play a crucial role in the treatment of various diseases, including pain, diabetes, cardiovascular diseases, and cancer. However, drug development targetin...

Academic Background Circulating DNA (cirdna) has garnered significant attention in recent years for its potential in tumor diagnosis, particularly in the field of liquid biopsy. cirdna not only aids in detecting tumor gene mutations but also plays a crucial role in treatment monitoring, cancer recurrence surveillance, and cancer screening. However,...