Cancer, as a major global public health challenge, is characterized by complex mechanisms underlying its onset and progression. For a long time, processes within the tumor microenvironment (TME)—such as immunity, inflammation, and angiogenesis—have been extensively studied and considered key determinants of tumor biological behavior. In recent year...
Cancer gene identification is a core challenge in the fields of basic cancer research and precision medicine. Recently, a research team from Jilin University and Zhejiang Sci-Tech University published an original study titled “Cancer gene identification through integrating causal prompting large language model with omics data–driven causal inferenc...
1. Research Background and Disciplinary Frontiers Cancer prognosis analysis has always been a core research direction in the medical field. In recent years, with the widespread application of high-throughput sequencing technologies, scientists have been able to delve deeper into exploring molecular biomarkers and clinical characteristics of cancer ...
Academic Background Bioluminescence technology is a highly sensitive and non-invasive imaging technique, enabling real-time monitoring in living organisms without the need for external light sources. Luciferase is the key enzyme that catalyzes the light-emitting reaction, but natural luciferases face multiple limitations, such as poor protein foldi...
Background Introduction Ferroptosis is a form of cell death triggered by iron-dependent lipid peroxidation, which has recently been recognized as having significant potential in cancer therapy. Cancer cells evade ferroptosis through various molecular alterations and metabolic reprogramming mechanisms, with glutathione peroxidase 4 (GPX4) being a ke...
Research Background In the tumor microenvironment, highly aggressive tumors evade immune system attacks by suppressing the cGAS-STING signaling pathway. The cGAS-STING pathway is a critical mechanism for cells to sense cytoplasmic double-stranded DNA and initiate immune responses. cGAS (cyclic GMP-AMP synthase) catalyzes the production of cGAMP upo...