Complex Neural-Immune Interactions Shape Glioma Immunotherapy

Medicine, Neurology, Oncology, Life Sciences, Immunology,
neural-immune interactions   glioma   immunotherapy   central nervous system   tumor microenvironment  

1. Academic Background Glioblastoma (GBM) and pediatric diffuse midline gliomas (e.g., H3K27M-mutant) are among the most aggressive tumors of the central nervous system (CNS), with limited efficacy from conventional treatments (surgery, radiotherapy, chemotherapy). For decades, the CNS was considered to have “immune privilege,” meaning the immune s...

VCP's Nuclear Journey: Initiated by Interacting with KPNB1 to Repair DNA Damage

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
DNA damage repair   VCP   KPNB1   nuclear translocation   Withaferin A  

Academic Background DNA damage repair (DDR) is a core mechanism for maintaining genome stability, and its dysfunction is closely associated with cancer development. Valosin-containing protein (VCP/p97), a member of the AAA+ ATPase family, plays a critical role in DDR by recognizing ubiquitinated proteins and recruiting repair factors (e.g., 53BP1, ...

Structural Insights into the Ubiquitin-Independent Midnolin-Proteasome Pathway

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
proteasome   ubiquitin-independent degradation   Midnolin   cryo-EM   B-cell malignancies  

Academic Background Protein homeostasis (proteostasis) is a core mechanism for maintaining normal cellular function, with the ubiquitin-proteasome system (UPS) responsible for degrading approximately 80% of abnormal proteins. Traditionally, proteins were thought to require ubiquitination for recognition and degradation by the 26S proteasome. Howeve...

Intercellular Contractile Force Attenuates Chemosensitivity Through Notch-MVP-Mediated Nuclear Drug Export

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Biophysics,
intercellular force   contractility   cell mechanics   mechanotransduction   chemosensitivity  

Academic Background Chemotherapy resistance is one of the major challenges in cancer treatment. Traditional research has primarily focused on biochemical mechanisms (e.g., drug efflux pumps, DNA repair, etc.), but in recent years, the role of biomechanical factors in tumor progression and drug resistance has gained increasing attention. Studies hav...

Benchmarking Copy Number Aberrations Inference Tools Using Single-Cell Multi-Omics Datasets

Information Science, Artificial Intelligence, Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
Single-cell RNA sequencing   Copy number aberrations   Tumor heterogeneity   Benchmarking   Multi-omics  

1. Research Background and Significance In the fields of oncology and genomics, chromosomal copy number alterations (CNAs) are a key type of genetic variation driving the occurrence and progression of cancer. CNAs not only determine tumor heterogeneity but also play a crucial role in early tumor detection, subclone evolution analysis, research on d...

Unveiling a Novel Cancer Hallmark by Evaluation of Neural Infiltration in Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
neural infiltration   cancer hallmark   tumor microenvironment   single-cell RNA sequencing   immunotherapy  

Cancer, as a major global public health challenge, is characterized by complex mechanisms underlying its onset and progression. For a long time, processes within the tumor microenvironment (TME)—such as immunity, inflammation, and angiogenesis—have been extensively studied and considered key determinants of tumor biological behavior. In recent year...