Electroacupuncture Ameliorated Locomotor Symptoms in MPTP-Induced Mice Model of Parkinson’s Disease by Regulating Autophagy via Nrf2 Signaling

Study on Electroacupuncture Improving Parkinson’s Disease Symptoms by Regulating Autophagy Academic Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, primarily characterized by the gradual loss of dopamine (DA) neurons in the substantia nigra of the midbrain and the abnormal accumulation of α-synucle...

Differential Effects of Stimulation Waveform and Intensity on the Neural Structures Activated by Lumbar Transcutaneous Spinal Cord Stimulation

The Differential Effects of Transcutaneous Spinal Cord Stimulation (TSS) on Neural Structure Activation Background Introduction Transcutaneous Spinal Cord Stimulation (TSS) is a non-invasive neurostimulation technique that applies electrical currents through electrodes on the skin surface to activate neural structures in the spinal cord, thereby el...

Machine Learning and Confirmatory Factor Analysis Show that Buprenorphine Alters Motor and Anxiety-like Behaviors in Male, Female, and Obese C57BL/6J Mice

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Increased Robustness and Adaptation to Simultaneous Temperature and Elevated Extracellular Potassium in the Pyloric Rhythm of the Crab, Cancer Borealis

Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...

The Discharge Characteristics of Motor Units Innervating Functionally Paralyzed Muscles

Study on the Discharge Characteristics of Motor Neurons Innervating Paralyzed Muscles after Spinal Cord Injury Academic Background Spinal Cord Injury (SCI) is a severe neurological injury that typically leads to the loss of motor and sensory functions below the injury level. Although patients clinically diagnosed with complete SCI are considered un...

Repeated Social Stress Increases Posterior Medial Amygdala Neuronal Activity in Stress-Susceptible Adult Male Rats

Effects of Repeated Social Stress on Neuronal Activity in the Posterior Medial Amygdala of Male Rats Background Social stress plays a crucial role in social behavior and mental health. Chronic social stress not only leads to changes in individual behavior but is also closely related to the development of various psychiatric disorders, such as anxie...

Applications of Transcranial Direct Current Stimulation over Vagus Nerve on Dysphagia after Stroke

Research on Transcranial Direct Current Stimulation Over Vagus Nerve for Post-Stroke Dysphagia Academic Background Stroke is the second leading cause of death worldwide, and survivors often face a range of complications, among which dysphagia is particularly common, with an incidence rate ranging from 27% to 64%. Dysphagia can lead to serious probl...

Sensory Processing in the Chilean Brush-tailed Mouse (Octodon degus): A Diurnal Precocial Rodent as a New Model to Study Visual Receptive Field Properties of Superior Colliculus Neurons

Academic Background The visual system is a crucial component for animals to perceive their external environment, and research on its development and function is essential for understanding the sensory mechanisms of mammals. However, traditional studies have predominantly relied on nocturnal or crepuscular laboratory rodents, such as mice, rats, and...

Motor Decision-Making under Uncertainty and Time Pressure

Research on Motor Decision-Making under Uncertainty and Time Pressure Academic Background In daily life, animals and humans often need to choose the most appropriate action from multiple possible options. However, how to plan and execute these actions under conditions of goal uncertainty and time pressure remains an incomplete question in neuroscie...