Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bioprinting   vascularization   skeletal muscle flaps   volumetric muscle loss   tissue engineering   perfusion   transplantation  

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Residual-Dense Network for Glaucoma Prediction Using Structural Features of Optic Nerve Head

Information Science, Artificial Intelligence, Medicine, Ophthalmology, Medical Imaging,
glaucoma   residual-dense network   optic nerve head   structural features   deep learning   optic cup   optic disc  

Using Residual Dense Network (RD-Net) for Glaucoma Prediction Based on Structural Features of the Optic Nerve Head Background and Research Purpose Glaucoma is one of the leading causes of blindness worldwide, often referred to as the “silent thief of sight.” It is characterized by the progressive degeneration of the optic nerve head (ONH), resultin...

Phase 1/2 Trial of Brogidirsen: Dual-Targeting Antisense Oligonucleotides for Exon 44 Skipping in Duchenne Muscular Dystrophy

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics,
Duchenne muscular dystrophy   exon skipping   antisense oligonucleotide   dual-targeting   Brogidirsen   biomarkers   muscle function stabilization  

New Advances in Dual-Targeting Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy: Phase 1⁄2 Clinical Trial of Brogidirsen Background Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder primarily affecting skeletal and cardiac muscles, leading to early loss of mobility and, eventually, organ failure. Currently, there is no ...

Hormone Therapy Enhances Anti-PD1 Efficacy in Premenopausal Estrogen Receptor-Positive and HER2-Negative Advanced Breast Cancer

Medicine, Rheumatology and Immunology, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hormone therapy   anti-PD1 antibody   estrogen receptor-positive breast cancer   HER2-negative   immune microenvironment   tumor immunotherapy  

Hormone Therapy Enhances Anti-PD-1 Efficacy: A Breakthrough Study Targeting Estrogen Receptor-Positive/HER2-Negative Metastatic Breast Cancer Background: Why Conduct This Study? In recent years, cancer immunotherapies have achieved transformative success, with notable efficacy in “hot tumors,” such as triple-negative breast cancer (TNBC), which hav...

High Cellular Plasticity State of Medulloblastoma: Local Recurrence and Distant Dissemination

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
medulloblastoma   cellular plasticity   recurrence   dissemination   PTPRZ1   tumor subpopulations   therapeutic target  

High Cellular Plasticity State of Pediatric Medulloblastoma: A Comprehensive Analysis of Local Recurrence and Distant Dissemination Research Background Medulloblastoma (MB) is a highly heterogeneous pediatric intracranial malignancy. While current treatments (surgery, radiotherapy, and chemotherapy) improve survival rates after initial treatment, r...