Super-Resolution Imaging of Fast Morphological Dynamics of Neurons in Behaving Animals

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
super-resolution imaging   neuronal morphological dynamics   behaving animals   structured illumination microscopy   neural plasticity  

Super-Resolution Imaging Reveals New Advances in Neural Morphodynamics in Mouse Brains: Dynamic Observations in Head-Fixed Awake Animals Background In the field of neuroscience, understanding the morphological changes and functional dynamics of neurons is key to deciphering how the brain processes information and sustains network plasticity. Despit...

An Organotypic Atlas of Human Vascular Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
vascular cells   single-cell transcriptomics   endothelial cells   mural cells   organotypic   molecular signatures   vascular diseases  

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

A Temporal Cortex Cell Atlas Highlights Gene Expression Dynamics During Human Brain Maturation

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
temporal cortex   single-nucleus RNA sequencing   brain maturation   gene expression   cell subtypes   cognition   synaptic plasticity  

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...

Single-cell RNA Sequencing of Peripheral Blood Links Cell-Type-Specific Regulation of Splicing to Autoimmune and Inflammatory Diseases

Medicine, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Single-cell RNA sequencing   Splicing regulation   Autoimmune diseases   Inflammatory diseases   Cell-type specificity   Genetic diversity   Asian Immune Diversity Atlas  

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

A Foundation Model for Joint Segmentation, Detection and Recognition of Biomedical Objects Across Nine Modalities

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Imaging,
biomedical image analysis   joint learning   segmentation   detection   recognition   multimodal   foundation model  

Decoding the Future of Biomedical Image Analysis: A Foundational Model for Multi-Modal Joint Segmentation, Detection, and Recognition Background In biomedical research, image analysis has become a crucial tool for advancing discoveries, enabling multi-scale studies ranging from organelles to organs. However, traditional biomedical image analysis of...

Repurposing Large-Format Microarrays for Scalable Spatial Transcriptomics

Medicine, Life Sciences, Biochemistry, Immunology, Genetics,
spatial transcriptomics   microarrays   high-throughput   tissue analysis   gene expression   biomedical research   clinical pathology  

A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...