Repurposing Large-Format Microarrays for Scalable Spatial Transcriptomics

Medicine, Life Sciences, Biochemistry, Immunology, Genetics,
spatial transcriptomics   microarrays   high-throughput   tissue analysis   gene expression   biomedical research   clinical pathology  

A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...

Efficient and Highly Amplified Imaging of Nucleic Acid Targets in Cellular and Histopathological Samples with PSABER

Medicine, Life Sciences, Cell Biology, Biochemistry, Genetics,
nucleic acid imaging   signal amplification   in situ hybridization   fluorescence microscopy   histopathology  

A New Platform for Efficient Signal Amplification of Nucleic Acid Targets in Tissue and Clinical Research: PSABER Background and Related Knowledge Since its first introduction by Pardue and Gall in the 1960s, in situ hybridization (ISH) has been widely adopted in research and clinical applications for its ability to spatially map nucleic acid targe...

A Benchmarked, High-Efficiency Prime Editing Platform for Multiplexed Dropout Screening

Medicine, Life Sciences, Genetics,
gene editing   multiplexed screening   high-efficiency editing   genomic variants   functional genomics  

Highly Efficient and Comprehensive Genome Editing Tool: A High-Performance Prime Editing Platform for Multiplexed Dropout Screening In the field of genome editing, Prime Editing has garnered significant attention for its precision and flexibility. This method allows for precise single-base substitutions and small insertions or deletions in the geno...

Evaluation of Large Language Models for Discovery of Gene Set Function

Information Science, Artificial Intelligence, Medicine, Life Sciences, Biochemistry, Genetics,
Large Language Models   Gene Set Function   Functional Genomics   Gene Ontology   Bioinformatics   Artificial Intelligence   Gene Expression  

Exploration of Gene Set Function Discovery Using Large Language Models: GPT-4 Excels Academic Background In functional genomics, gene set enrichment analysis is a critical methodology for understanding gene functions and their associated biological processes. However, existing enrichment analyses rely heavily on curated gene function databases, suc...

ONIX: A Unified Open-Source Platform for Multimodal Neural Recording and Perturbation During Naturalistic Behavior

Medicine, Neurology, Life Sciences, Bioengineering,
neural recording   naturalistic behavior   open-source platform   multimodal   low latency   mouse experiments   neuroscience  

ONIX: An Open-Source Platform for Multimodal Neural Recording and Perturbation During Naturalistic Behavior Research Background and Significance In recent years, significant advances have been made in large-scale neural population recording technology and studies on animal behavior in the field of neuroscience. However, these two demands often conf...

Fully Automated Sample-to-Result Simple-RPA Microfluidic Chip for In Ovo Sexing Application

Chemistry, Analytical Chemistry, Engineering, Mechanical Engineering, Medicine, Life Sciences, Bioengineering,
microfluidic chip   in ovo sexing   recombinase polymerase amplification   automated detection   low cost   high sensitivity   animal welfare  

Fully Automated Microfluidic Chip-Based Embryo Sexing Technology Academic Background In the egg-laying poultry industry, newly hatched male chicks are often culled immediately after hatching, as they neither lay eggs nor produce high-quality meat. Each year, approximately 372 million male chicks are culled in the European Union. This practice has s...