Fully Automated Sample-to-Result Simple-RPA Microfluidic Chip for In Ovo Sexing Application

Chemistry, Analytical Chemistry, Engineering, Mechanical Engineering, Medicine, Life Sciences, Bioengineering,
microfluidic chip   in ovo sexing   recombinase polymerase amplification   automated detection   low cost   high sensitivity   animal welfare  

Fully Automated Microfluidic Chip-Based Embryo Sexing Technology Academic Background In the egg-laying poultry industry, newly hatched male chicks are often culled immediately after hatching, as they neither lay eggs nor produce high-quality meat. Each year, approximately 372 million male chicks are culled in the European Union. This practice has s...

Direct Observation of Small Molecule Activator Binding to Single PR65 Protein

Chemistry, Medicinal Chemistry, Medicine, Life Sciences, Biochemistry, Biophysics,
Protein Phosphatase 2A   Small Molecule Activator   Nanoaperture Optical Tweezers   Binding Kinetics   Molecular Dynamics Simulation  

Single-Molecule Optical Tweezer Technique Reveals the Binding Mechanism of a Small Molecule Activator and PR65 Protein Academic Background Protein phosphatase 2A (PP2A) is a crucial enzyme in regulating cellular signaling. Its dysfunction is closely associated with various cancers and chronic diseases, such as Alzheimer’s disease and chronic obstru...

The Development and Application of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Bioengineering,
levodopa   Parkinson's disease   direct electron transfer enzyme   biosensor   continuous monitoring  

Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...

Advancements of Paper-Based Sensors for Antibiotic-Resistant Bacterial Species Identification

Chemistry, Nanoscience, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
paper-based sensors   antibiotic resistance   bacterial infections   nanoparticles   detection techniques  

Advances in Paper-Based Sensors for the Detection of Antibiotic-Resistant Bacteria Background Antimicrobial resistance (AMR) is one of the most significant global public health challenges today. With the extensive use and misuse of antibiotics, more and more bacteria have developed resistance, rendering traditional treatments ineffective. According...

Evaluation of Electrical Impedance Spectroscopy of Bovine Eyes for Early Detection of Uveal Melanoma

Evaluation of Electrical Impedance Spectroscopy of Bovine Eyes for Early Detection of Uveal Melanoma

Medicine, Ophthalmology, Medical Imaging, Oncology, Life Sciences, Bioengineering,
Electrical Impedance Spectroscopy   Uveal Melanoma   Early Detection   Bovine Eye Model   Finite Element Analysis  

Early Detection of Uveal Melanoma Using Electrical Impedance Spectroscopy Academic Background Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high aggressiveness, which can lead to vision loss and even life-threatening outcomes. Early detection and timely treatment are crucial for preserving vision ...

Resolving Native GABAA Receptor Structures from the Human Brain

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
GABAA receptor   structural analysis   epilepsy   cryo-electron microscopy   drug binding   neurotransmitter   human brain  

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...