Novel Heart Valve Leaflet Designs with Stiff Polymeric Materials and Biomimetic Kinematics

Materials Science, Organic Polymeric Materials, Medicine, Cardiovascular System, Life Sciences, Bioengineering,
heart valve   polymeric materials   biomimetic design   hemodynamics   finite element analysis   in vitro testing   leaflet kinematics  

Novel Heart Valve Leaflet Design: Research Based on High-Stiffness Polymeric Materials and Biomimetic Kinematics Academic Background Heart valve disease is a significant global health issue, with over 850,000 patients requiring heart valve replacement surgery annually. Currently, the heart valves used in clinical practice are mainly divided into tw...

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Medicine, Orthopedics, Life Sciences, Biochemistry, Bioengineering,
bone organoid   endochondral ossification   T-type voltage-dependent calcium channel   Cav3.3   3D bioprinting   GelMA hydrogel   chondrocyte differentiation  

Study on Cav3.3-Mediated Endochondral Ossification in 3D Bioprinted GelMA Hydrogel Research Background Bone development is a complex process, in which the growth plate (GP) plays a crucial role in the longitudinal growth of long bones. The growth plate regulates bone maturation through the process of endochondral ossification (EO). However, GP dysf...

Photocrosslinkable Human Amniotic Membrane Hydrogel for Recovery from Spinal Cord Injury

Medicine, Neurology, Life Sciences, Bioengineering,
spinal cord injury   nerve regeneration   human acellular amniotic membrane   composite hydrogel   biological materials  

Photocrosslinked Human Amniotic Membrane Hydrogel for Spinal Cord Injury Repair Academic Background Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to loss of motor function and a decline in the quality of life for patients. Despite significant advancements in tissue engineering and regenerative medicine in recent years,...

3D Bioprinting of Tumor Models and Potential Applications

Medicine, Oncology, Life Sciences, Bioengineering,
3D bioprinting   tumor models   tumor microenvironment   bioinks   drug screening   precision medicine   tumor immunotherapy  

3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...

3D-Bioprinted Tri-Layered Cellulose/Collagen-Based Drug-Eluting Fillers for the Treatment of Deep Tunneling Wounds

Materials Science, Medicine, Life Sciences, Bioengineering,
3D bioprinting   tunneling wounds   cellulose   collagen   drug-eluting   stem cells   wound healing  

3D Bioprinted Cellulose/Collagen-Based Drug-Eluting Fillers for the Treatment of Deep Tunneling Wounds Academic Background Deep tunneling wounds are complex injuries that form beneath the skin surface, varying in shape and size, and may have twists and turns, making treatment extremely challenging. Current wound care solutions primarily target supe...

Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
nanocontainer   tumor hypoxia   photodynamic therapy   chemodynamic therapy   Fenton effect   multimodal therapy   targeted therapy  

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...