Diagnostic Guidelines for Familial Hemophagocytic Lymphohistiocytosis Revisited

Medicine, Pediatrics, Hematology, Life Sciences, Immunology, Genetics,
Familial Hemophagocytic Lymphohistiocytosis   Diagnostic Criteria   HLH-2004   Cellular Cytotoxicity Assays   Genetic Diagnosis  

Revisited Diagnostic Guidelines for Familial Hemophagocytic Lymphohistiocytosis (FHL) Based on HLH-2004: Updates to Diagnostic Criteria and Development of Multipathway Diagnostic Strategies Introduction Familial hemophagocytic lymphohistiocytosis (FHL) is a severe hyperinflammatory disease characterized by abnormal accumulation of macrophages and l...

Structural Adaptations of von Willebrand Factor, Factor VIII, and Factor IX in Hemostasis

Medicine, Hematology, Life Sciences,
von Willebrand factor   factor VIII   factor IX   hemostasis   structural adaptations   thrombus formation   von Willebrand disease  

Review Report on the Paper: Structural Adaptations of Von Willebrand Factor, Factor VIII, and Factor IX to Coordinate Complex Functions Background and Research Motivation Coagulation factors are crucial elements of maintaining the dynamic balance of the hemostatic system. Among them, von Willebrand Factor (VWF) plays a central role in hemostasis, p...

JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 Cells: Final Phase 2 Trial Results

Medicine, Hematology, Life Sciences, Immunology,
JAK2/mTOR inhibition   acute GVHD   Th1/Th17 cells   allogeneic hematopoietic cell transplantation   clinical trial   immunosuppression   cell differentiation  

Inhibition of JAK2/mTOR Fails to Effectively Prevent Acute Graft-versus-Host Disease (GVHD): Limitations of Targeting Th1/Th17 Cells In recent years, the role of systemic immunosuppressive therapies in preventing acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (alloHCT) has come under scrutiny. Th1 (T...

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Putative Liver Roles

Medicine, Hepatobiliary System, Hematology, Cardiovascular System, Life Sciences, Genetics,
plasma fibrinogen   whole-genome analysis   genetic regulation   population differentiation   liver roles   genetic variation   biomarkers  

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...

Gene Therapy: Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices

Medicine, Hematology, Life Sciences,
gene therapy   platelets   mRNA-lipid nanoparticles   blood banking   transfusion   cell therapy   clinical compatibility  

Report on the Compatibility of mRNA-Lipid Nanoparticle-Based Gene-Engineered Platelets with Blood Banking Practices Academic Background Platelets play an essential role in hemostasis, inflammation, sepsis, and cancer. However, clinical applications of platelet transfusions are primarily limited to managing thrombocytopenia and bleeding. To broaden ...

Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients with AML Treated with Venetoclax and Azacitidine

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Venetoclax   Azacitidine   Genetic Risk Stratification   Prognostic Model   TP53 Mutation   FLT3-ITD Mutation  

Genetic Risk Stratification and Outcomes Among Treatment-Naive AML Patients Treated with Venetoclax and Azacitidine Academic Background Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with prognosis closely related to the genetic characteristics of patients. The European LeukemiaNet (ELN) 2017 and 2022 risk stratifica...