Lactate Secreted by Glycolytic Conjunctival Melanoma Cells Attracts and Polarizes Macrophages to Drive Angiogenesis in Zebrafish Xenografts

Medicine, Ophthalmology, Oncology, Life Sciences, Immunology,
angiogenesis   conjunctival melanoma   macrophages   glycolysis   lactate   zebrafish model  

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...

Botulinum Neurotoxin Serotype A Inhibited Ocular Angiogenesis through Modulating Glial Activation via SOCS3

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Botulinum Neurotoxin Serotype A   Choroidal Neovascularization   Age-Related Macular Degeneration   Glial Activation   Müller Activation   Microglial Activation   SOCS3  

Academic Background Age-related macular degeneration (AMD) is a major cause of central vision loss among the elderly, particularly in its neovascular (NV) form, where choroidal neovascularization (CNV) leads to rapid and severe vision loss. Current AMD treatments primarily rely on intravitreal injections of anti-vascular endothelial growth factor (...

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues

Medicine, Cardiovascular System, Life Sciences, Cell Biology,
ALK1   Endoglin   hemodynamic cues   vein cells   arteriovenous malformations   zebrafish   hereditary hemorrhagic telangiectasia  

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues Academic Background The normal development and function of the vascular system rely on precise regulation of blood vessel diameter. Hemodynamic cues, such as fluid shear stress (FSS), are considered critical factors in regulating vessel diameter. According to...

Somatic RIT1 Delins in Arteriovenous Malformations Hyperactivate RAS-MAPK Signaling Amenable to MEK Inhibition

Medicine, Oncology, Life Sciences, Immunology, Genetics,
arteriovenous malformation   RIT1 gene   RAS-MAPK signaling   MEK inhibitor   vascular anomalies  

Academic Background and Problem Statement Arteriovenous Malformations (AVMs) are benign vascular anomalies prone to pain, bleeding, and progressive growth. The primary cause of AVMs is somatic mutations in the RAS-MAPK signaling pathway. However, not all patients have identifiable causative mutations. To further explore the pathogenesis of AVMs, re...

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice

Medicine, Cardiovascular System,
aortic aneurysm   endothelial cells   heterogeneity   site-specificity   RNA-seq  

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...

Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...