Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients with AML Treated with Venetoclax and Azacitidine

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Venetoclax   Azacitidine   Genetic Risk Stratification   Prognostic Model   TP53 Mutation   FLT3-ITD Mutation  

Genetic Risk Stratification and Outcomes Among Treatment-Naive AML Patients Treated with Venetoclax and Azacitidine Academic Background Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with prognosis closely related to the genetic characteristics of patients. The European LeukemiaNet (ELN) 2017 and 2022 risk stratifica...

Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study

Medicine, Pediatrics, Hematology, Oncology, Life Sciences, Immunology,
Daratumumab   Acute Lymphoblastic Leukemia   Lymphoblastic Lymphoma   Pediatric   Relapsed/Refractory   DELPHINUS Study   Chemotherapy  

Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study Academic Background Acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL) are among the most common malignancies in children. Although the cure rate for newly diagnosed ALL and LL patients is relatively high, 10% to ...

Effect of Oral Nintedanib vs Placebo on Epistaxis in Hereditary Hemorrhagic Telangiectasia: The EPICURE Multicenter Randomized Double-Blind Trial

Medicine, Hematology,
Hereditary Hemorrhagic Telangiectasia   Epistaxis   Anti-angiogenic   Nintedanib   Anemia   Tyrosine Kinase Inhibitors  

The Effect of Oral Nintedanib vs Placebo on Epistaxis in Hereditary Hemorrhagic Telangiectasia: The EPICURE Multicenter Randomized Double-Blind Trial Academic Background Hereditary Hemorrhagic Telangiectasia (HHT) is a rare genetic disorder characterized by vascular malformations, particularly capillary dilatations. Epistaxis (nosebleeds) is the mo...

Neuropilin-1 Controls Vascular Permeability through Juxtacrine Regulation of Endothelial Adherens Junctions

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Neuropilin-1   vascular permeability   signalling   VE-cadherin   VEGFA  

Neuropilin-1 (Nrp1) is a multifunctional transmembrane protein that is abundantly expressed on the surface of various cell types, where it binds to class 3 semaphorins (Sema3), heparan sulfate, and vascular endothelial growth factors (VEGFs). Nrp1 plays a crucial role in angiogenesis and vascular permeability regulation, particularly in the VEGF si...

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Hereditary Hemorrhagic Telangiectasia   Arteriovenous Malformation   Endothelial Cells   mTORC1   Signaling Pathways   Genetic Targeting   Pharmacological Treatment  

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused by mutations leading to the loss of function in either Activin Receptor-Like Kinase 1 (ACVRL1) or Endoglin (ENG), which act as receptors a...

Lactate Secreted by Glycolytic Conjunctival Melanoma Cells Attracts and Polarizes Macrophages to Drive Angiogenesis in Zebrafish Xenografts

Medicine, Ophthalmology, Oncology, Life Sciences, Immunology,
angiogenesis   conjunctival melanoma   macrophages   glycolysis   lactate   zebrafish model  

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...