Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease

Medicine, Rheumatology and Immunology, Hematology, Oncology, Life Sciences, Cell Biology, Immunology,
acute graft-versus-host disease   allogeneic hematopoietic cell transplantation   cellular therapy   T-cell depletion   mesenchymal stem cells   regulatory T cells   immunomodulation  

Advances in Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease (aGVHD) — An Authoritative Review on the Paper “Cellular therapies for the prevention and treatment of acute graft-versus-host disease” 1. Academic Background and Motivation Acute graft-versus-host disease (aGVHD) is one of the most severe complicatio...

Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes

Medicine, Pediatrics, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
inherited bone marrow failure syndromes   inflammation   pro-inflammatory cytokines   bone marrow microenvironment   mesenchymal stromal cells   hematopoietic stem cells   cytokine network  

Inflammatory Pathways and Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes: New Insights into Chronic Inflammation Research Background and Academic Significance Inherited bone marrow failure syndromes (IBMFS) are a group of genetic disorders characterized by reduced hematopoietic cell production due to blood stem cell dysfunc...

RUNX1 is a Key Inducer of Human Hematopoiesis Controlling Non-Hematopoietic Mesodermal Development

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
RUNX1   hematopoiesis   non-hematopoietic mesoderm   mesenchymal cells   transcription factor   human development   stem cell differentiation  

The Dominant Role of RUNX1 in Human Hematopoietic Development and Mesodermal Fate Balance — An Interpretation of “runx1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development” 1. Academic Background and Research Motivation The development of the hematopoietic system is fundamental for the growth and maintenance...

Monocytes Use Protrusive Forces to Generate Migration Paths in Viscoelastic Collagen-Based Extracellular Matrices

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology, Biophysics,
monocyte   cell migration   extracellular matrix   viscoelasticity   tumor microenvironment   collagen   protrusive force  

New Mechanism of Immune Cell Migration Revealed: How Monocytes “Pioneer Their Path” in the Tumor Microenvironment I. Academic Research Background and the Central Question Cell migration is a crucial biological process in life, encompassing embryonic development, tissue repair, immune responses, and the progression of various diseases. In the contex...

Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
antisense oligonucleotide   splicing mutation   hotspot exon   RNA splicing   actionable genes   gene mutation   therapeutic strategy  

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...

Complex Neural-Immune Interactions Shape Glioma Immunotherapy

Medicine, Neurology, Oncology, Life Sciences, Immunology,
neural-immune interactions   glioma   immunotherapy   central nervous system   tumor microenvironment  

1. Academic Background Glioblastoma (GBM) and pediatric diffuse midline gliomas (e.g., H3K27M-mutant) are among the most aggressive tumors of the central nervous system (CNS), with limited efficacy from conventional treatments (surgery, radiotherapy, chemotherapy). For decades, the CNS was considered to have “immune privilege,” meaning the immune s...