Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

Mitochondria-Enriched Hematopoietic Stem Cells Exhibit Elevated Self-Renewal Capabilities Within the Context of Aged Bone Marrow

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
hematopoietic stem cells   mitochondria   self-renewal   aging   bone marrow   single-cell analysis   cell differentiation  

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Activation of AMPK by GLP-1R Agonists Mitigates Alzheimer-Related Phenotypes in Transgenic Mice

Medicine, Basic Medical Sciences, Geriatrics, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry,
GLP-1R agonists   AMPK   Alzheimer's disease   transgenic mice   neuroprotection   amyloid-beta   diabetes  

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...

Large-Scale Network Analysis of the Cerebrospinal Fluid Proteome Reveals Molecular Signatures of Frontotemporal Lobar Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
frontotemporal lobar degeneration   cerebrospinal fluid   proteomics   network analysis   genetic mutations   biomarkers  

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

The Role of mRNA Metabolism Regulator Human Antigen R (HuR) in Age-Related Hearing Loss in Aged Mice

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
mRNA metabolism   HuR   age-related hearing loss   hair cells   auditory function   AAV gene therapy   cochlea  

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...