Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...
C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...
A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...
New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...
The Effect of Calcium-Activated Potassium Channels (SK Channels) on Repolarization in Failing Ventricular Myocytes—A Computational Modeling Study Research Background and Academic Significance Heart failure (HF) is a severe and prevalent cardiac disease, characterized by a comprehensive deterioration of the heart’s electrophysiological and contracti...
Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...
From Digital Twin to Virtual Human Twin: A “Moonshot” Project in Digital Health 1. Academic Background and Research Motivation Currently, the global healthcare system continues to face numerous unmet clinical and social needs, which manifest as a lack of treatment options, insufficient and expensive medical resources, lengthy waiting times, and ina...