New Breakthrough in Disease-Agnostic Remote Speech Health Diagnostic Models—An Interpretation of “wavrx: a disease-agnostic, generalizable, and privacy-preserving speech health diagnostic model” 1. Research Background and Introduction With the ongoing rise in demand for telemedicine and health management, realizing real-time, non-invasive, and auto...
Interpretation of “EVOMOE: Evolutionary Mixture-of-Experts for SSVEP-EEG Classification with User-Independent Training” 1. Research Background and Problem Statement Brain-computer interface (BCI) technology has recently shown broad application prospects in neuroengineering, assistive technology for disabilities, rehabilitation, emotion recognition,...
Multimodal Cardiovascular Waveform Generation from a Single Vibrational Cardiography Sensor Background Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, affecting hundreds of millions of patients each year and imposing a tremendous burden on global healthcare systems. According to literature, billions o...
New Breakthrough in Intelligent Medical Diagnosis: Randomized Explainable Machine Learning Models Drive Efficient Medical Diagnostics I. Academic Background and Research Motivation In recent years, Deep Learning (DL) models have played a crucial role in the field of healthcare. By processing vast amounts of medical data, DL significantly improves t...
From Digital Twin to Virtual Human Twin: A “Moonshot” Project in Digital Health 1. Academic Background and Research Motivation Currently, the global healthcare system continues to face numerous unmet clinical and social needs, which manifest as a lack of treatment options, insufficient and expensive medical resources, lengthy waiting times, and ina...
1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...
Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...
1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...
Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...
1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...