The Dominant Role of RUNX1 in Human Hematopoietic Development and Mesodermal Fate Balance — An Interpretation of “runx1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development” 1. Academic Background and Research Motivation The development of the hematopoietic system is fundamental for the growth and maintenance...

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...

I. Academic Background: The Cardiac Mystery Facing Regenerative Medicine Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide due to heart damage. However, the adult mammalian heart has long been regarded as having essentially lost its endogenous regenerative ability, with th...

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...

1. Academic Background Since the origin of life, living organisms have needed to construct effective barriers to protect their cells from external physical and chemical damage. In the realms of bacteria and archaea, the surface layer (S-layer) is a universally present and exquisitely structured two-dimensional protein lattice that substitutes for t...

New Mechanism of Immune Cell Migration Revealed: How Monocytes “Pioneer Their Path” in the Tumor Microenvironment I. Academic Research Background and the Central Question Cell migration is a crucial biological process in life, encompassing embryonic development, tissue repair, immune responses, and the progression of various diseases. In the contex...

Academic Background and Research Motivation The cytoskeleton is the core structural support responsible for maintaining cell morphology and mechanical properties and is mainly composed of three major classes: actin filaments, microtubules, and intermediate filaments. Among these, intermediate filaments play an irreplaceable role in maintaining cell...

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...