Clinicogenomic Landscape of Pancreatic Adenocarcinoma Identifies KRAS Mutant Dosage as Prognostic of Overall Survival

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
pancreatic cancer   KRAS mutation   genomic landscape   prognostic marker   clinical study  

Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...

High-Efficiency Base Editing in the Retina of Primates and Human Tissues

Medicine, Ophthalmology, Life Sciences, Biochemistry, Bioengineering, Genetics,
base editing   retina   gene therapy   primates   Stargardt disease  

High-precision Base Editing Technology in Primates and Human Retina Research Background Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. The protein encoded by the ABCA4 gene is a membrane lipid flippase localized i...

Reduced-Energy Diet in Women with Gestational Diabetes: The Dietary Intervention in Gestational Diabetes DIGEST Randomized Clinical Trial

Medicine, Obstetrics and Gynecology, Endocrinology,
Gestational Diabetes   Reduced-Energy Diet   Randomized Clinical Trial   Weight Management   Perinatal Outcomes  

Research Report on Low-Energy Diet Intervention in Gestational Diabetes Academic Background Gestational Diabetes Mellitus (GDM) is a form of diabetes diagnosed for the first time during pregnancy, with a global incidence rate of approximately 6-15%. GDM not only increases the risk of short-term complications for both mothers and fetuses, such as la...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Medicine, Respiratory System, Emergency Medicine, Cardiovascular System,
High-risk pulmonary embolism   Systemic thrombolysis   Surgical thrombectomy   Percutaneous catheter-directed treatment   Mechanical circulatory support  

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study

Medicine, Neurology,
mechanical ventilation   acute brain injury   traumatic brain injury   cerebrovascular disease   outcome  

Academic Report on “Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study” Academic Background Mechanical ventilation (MV) is a fundamental component of the intensive care unit (ICU) management of acute brain injury (ABI) patients. However, strong evidence on the best ven...

Discussing Expected Long-Term Quality of Life in the ICU: Effect on Experiences and Outcomes of Patients, Family, and Clinicians—A Randomized Clinical Trial

Medicine, Nursing, Emergency Medicine, Psychiatry, Clinical Psychology,
critical care outcomes   shared decision-making   quality of life   prediction model   ICU   depression symptoms   clinician collaboration  

The Impact of Discussing Long-Term Quality of Life Predictions in the ICU on Patients, Families, and Healthcare Professionals Academic Background Patients discharged from the Intensive Care Unit (ICU) often face a range of physical, psychological, and cognitive issues, collectively referred to as Post-Intensive Care Syndrome (PICS). Despite improve...

Persistent Severe Acute Kidney Injury is a Major Modifiable Determinant of Outcome During Critical Illness

Medicine, Nephrology,
Acute Kidney Injury   Critical Illness   Renal Recovery   Risk Factors   Renal Replacement Therapy  

The Impact of Persistent Severe Acute Kidney Injury on Outcomes in Critically Ill Patients Background Introduction Acute Kidney Injury (AKI) is a common complication among hospitalized and critically ill patients, causing over 10 million deaths globally each year and serving as a significant risk factor for the progression of Chronic Kidney Disease...

ESICM Consensus-Based Recommendations for the Management of Very Old Patients in Intensive Care

Medicine, Emergency Medicine, Geriatrics, Anesthesiology,
critical care   delphi study   emergency medicine   geriatric medicine   very old patients  

ESICM Consensus: Management and Challenges of Very Old Patients in Critical Care Academic Background With the global aging population, the proportion of “very old patients” (aged 80 years and above) in intensive care units (ICUs) is rapidly increasing. This group is characterized by functional impairments and a high prevalence of complex multimorbi...

Are Contemporary Antifungal Doses Sufficient for Critically Ill Patients? Outcomes from an International, Multicenter Pharmacokinetics Study for Screening Antifungal Exposure in Intensive Care Units—The SAFE-ICU Study

Medicine, Infectious Diseases, Pharmacy,
antifungals   pharmacokinetics   intensive care unit   invasive fungal disease   dose optimization  

International Multicenter Study Reveals Insufficient Antifungal Dosing in Critically Ill Patients Academic Background Invasive fungal infections are common and serious nosocomial infections, particularly among patients in the intensive care unit (ICU), where they are associated with high morbidity and mortality rates. Timely and appropriate antifun...

Impact of Rapid ICU-Based Syndromic PCR on Antibiotic Stewardship and Clinical Outcomes in Hospital-Acquired and Ventilator-Associated Pneumonia

Medicine, Infectious Diseases, Medical Laboratory Science,
Hospital-acquired pneumonia   Ventilator-associated pneumonia   Multiplex PCR   Antibiotic stewardship   Clinical outcomes  

INHALE WP3 Study - The Impact of Rapid PCR on ICU Antibiotic Stewardship and Clinical Outcomes Background Introduction Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are common infections in intensive care unit (ICU) patients, with an incidence rate between 5% to 40%, and are associated with high morbidity and increased...