Multimodal Neuroimaging Study on Cognitive Impairment in Parkinson’s Disease Parkinson’s Disease (PD) is a common neurodegenerative disorder mainly characterized by motor impairments. However, cognitive impairment (CI), one of the non-motor symptoms, significantly affects patients’ quality of life. According to extensive epidemiological studies, ap...
Breakthrough in Nuclear Medicine and Molecular Imaging: European Study Reveals Application of One-Day Dual-Tracer PET/CT Imaging in Neuroendocrine Tumors In the field of nuclear medicine, neuroendocrine neoplasms (NENs), known for their heterogeneity and complexity, have consistently been a focal point of research. A team from Tübingen, Germany, ha...
A Transformer Model Integrating PET Imaging and Clinical Data: A Multicenter Digital Biopsy Study for Predicting Pathological Grading and Prognosis of Follicular Lymphoma Academic Background Follicular Lymphoma (FL) is the most common indolent Non-Hodgkin Lymphoma in Western countries, accounting for approximately 30% of newly diagnosed cases. Acco...
Revealing Gene Expression Patterns Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy Background Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy, and its pathological features and mechanisms have long drawn extensive attention in the field of neuroscience. This disorder involves not only a single b...
Background In recent years, significant progress has been made in the field of cancer diagnosis and treatment, particularly in technologies based on molecular imaging and targeted radiotherapy. Among these, Fibroblast Activation Protein (FAP), a biomarker highly expressed in the tumor microenvironment, has garnered widespread attention. FAP is prim...
Application of Explainable Machine Learning in Amino Acid PET Imaging for Glioma Diagnosis Academic Background Gliomas are among the most common malignant tumors of the central nervous system, with their diagnosis and treatment strategies typically relying on histopathological analysis. However, histopathology has limitations such as being highly i...
Application of AI-Enhanced Ultra-Fast PSMA-PET in Prostate Cancer Staging Academic Background Prostate cancer is one of the most common cancers among men globally, and accurate diagnosis and staging are crucial for treatment decision-making. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has become a standard examinati...
Early-phase 18F-Flortaucipir Tau-PET as a Proxy for Brain Metabolism in Alzheimer’s Disease Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition, intracellular pathological tau protein accumulation, and neurodegeneration. These pathological changes begin accumulating in ...
REF-1 Overexpression in Neovascular Eye Diseases and Therapeutic Targeting with a Novel Inhibitor Academic Background Neovascular age-related macular degeneration (nAMD) is a common blinding eye disease predominantly affecting individuals aged 60 years and older. nAMD is characterized by the formation of subretinal neovascularization, leading to re...
Anti-Angiogenic Therapy as a Potential Treatment for Adenomyosis Academic Background Adenomyosis is a common gynecological condition characterized by endometrial tissue invading the myometrium, resulting in abnormal uterine bleeding, dysmenorrhea, and infertility. Despite its significant impact on women’s quality of life and public health, the etio...