DDX24 Spatiotemporally Orchestrates VEGF and Wnt Signaling During Developmental Angiogenesis

Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
angiogenesis   endothelial cells   spatial transcriptomics   VEGF   DDX24  

Research Background Vascular system development is a highly precise regulatory process involving two key stages: vasculogenesis and angiogenesis. Although the VEGF (vascular endothelial growth factor) and Wnt signaling pathways have been confirmed to regulate vascular development in the peripheral and central nervous systems (CNS), respectively, th...

NF-κB-Mediated Developmental Delay Extends Lifespan in Drosophila

Medicine, Rheumatology and Immunology, Endocrinology, Life Sciences, Cell Biology, Immunology, Genetics,
developmental delay   lifespan extension   NF-κB signaling   innate immunity   Drosophila  

1. Research Background Aging has long been viewed as a gradual decline in physiological function with age. However, mounting evidence indicates that developmental programs profoundly influence aging outcomes. For instance, developmental time (the time required for an organism to reach maturity) shows a significant positive correlation with adult li...

Differential Elimination of Marked Sex Chromosomes Enables Production of Nontransgenic Male Mosquitoes in a Single Strain

Medicine, Infectious Diseases, Life Sciences, Bioengineering, Genetics,
mosquito control   sex-separation   homomorphic sex chromosome   recessive lethal   sterile insect technique  

Research Background The Aedes aegypti mosquito is a primary vector for arboviruses such as dengue and Zika. Current genetic control strategies relying on the release of non-biting males (e.g., Sterile Insect Technique, SIT, or Wolbachia-based Incompatible Insect Technique, IIT) face a critical bottleneck: how to efficiently and cost-effectively iso...

VCP's Nuclear Journey: Initiated by Interacting with KPNB1 to Repair DNA Damage

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
DNA damage repair   VCP   KPNB1   nuclear translocation   Withaferin A  

Academic Background DNA damage repair (DDR) is a core mechanism for maintaining genome stability, and its dysfunction is closely associated with cancer development. Valosin-containing protein (VCP/p97), a member of the AAA+ ATPase family, plays a critical role in DDR by recognizing ubiquitinated proteins and recruiting repair factors (e.g., 53BP1, ...

Structural Insights into the Ubiquitin-Independent Midnolin-Proteasome Pathway

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
proteasome   ubiquitin-independent degradation   Midnolin   cryo-EM   B-cell malignancies  

Academic Background Protein homeostasis (proteostasis) is a core mechanism for maintaining normal cellular function, with the ubiquitin-proteasome system (UPS) responsible for degrading approximately 80% of abnormal proteins. Traditionally, proteins were thought to require ubiquitination for recognition and degradation by the 26S proteasome. Howeve...

Cyclic Peptide Inhibitors Function as Molecular Glues to Stabilize Gq/11 Heterotrimers

Chemistry, Medicinal Chemistry, Medicine, Life Sciences, Biochemistry, Biophysics,
cyclic peptide inhibitors   molecular glues   Gq/11 heterotrimers   X-ray crystallography   BRET biosensors  

Academic Background G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body, transmitting extracellular signals through heterotrimeric G proteins (composed of Gα and Gβγ subunits). G proteins function as molecular switches, with their activity states regulated by the GTP/GDP cycle: - Inactive state: Gα bind...