— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...
1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...
I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...
Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...
1. Research Background and Significance Over the past decade, the role of epigenetics in regulating cell fate decisions and disease development has become increasingly prominent. As a crucial part of epigenetic regulation, modifications at the RNA level—especially N6-methyladenosine (m6A)—have been confirmed to be widely present within eukaryotic m...
Research Background and Academic Significance Olfaction is one of the most important ways for humans to sense the external environment, fundamentally relying on olfactory sensory neurons (OSNs) in the olfactory epithelium (OE). These neurons possess the ability to regenerate throughout life, primarily due to the presence of local basal stem cell po...