Single-dose Psilocybin Rapidly and Sustainably Relieves Allodynia and Anxiodepressive-like Behaviors in Mouse Models of Chronic Pain

Medicine, Basic Medical Sciences, Psychiatry, Anesthesiology, Neurology, Clinical Psychology, Pharmacy,
chronic pain   psilocybin   allodynia   anxiodepression   5-HT receptors   prefrontal cortex   neural circuits  

Single-dose Psychedelic Rapidly and Sustainedly Relieves Chronic Pain and Emotional Disorders: Academic Report on New Original Research in Nature Neuroscience Background Chronic pain and emotional disorders (such as anxiety and depression) frequently co-occur in clinical settings, each exacerbating the other and affecting treatment outcomes. Clinic...

Temporal Integration in Human Auditory Cortex is Predominantly Yoked to Absolute Time

Information Science, Artificial Intelligence, Medicine, Neurology, Life Sciences, Biophysics,
Auditory cortex   Temporal integration   Speech structure   Neural computation   Electrophysiology   Time-yoked   Structure-yoked  

Temporal Integration Mechanisms in the Human Auditory Cortex: Neural Computation Is Predominantly Tied to Absolute Time In recent years, the mechanisms of temporal integration in the brain during the processing of sound structure—especially in speech and music comprehension—have attracted widespread attention in neuroscience. Sound signals, such as...

Embryonic Motor Neuron Programming Factors Reactivate Immature Gene Expression and Suppress ALS Pathologies in Postnatal Motor Neurons

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
motor neuron   ALS   transcription factors   gene expression   neurodegeneration   reprogramming   gene therapy  

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

Oxytocin Modulates Respiratory Heart Rate Variability Through a Hypothalamus–Brainstem–Heart Neuronal Pathway

Medicine, Respiratory System, Basic Medical Sciences, Psychiatry, Endocrinology, Neurology, Cardiovascular System, Life Sciences, Biochemistry,
oxytocin   respiratory heart rate variability   hypothalamus-brainstem pathway   cardiac regulation   vagus nerve   stress recovery   neural modulation  

Latest Nature Neuroscience Research Report: A Novel Central Mechanism of Oxytocin in Regulating Respiratory Heart Rate Variability 1. Research Background and Disciplinary Foundation Heart rate variation is an important indicator reflecting both physiological and psychological states in humans, finely regulated by the autonomic nervous system to mai...

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
muscle-derived miR-126   TDP-43 axonal synthesis   neuromuscular junction   ALS models   neurodegeneration   local protein synthesis  

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
C9orf72   hexanucleotide repeat expansion   microglia   amyotrophic lateral sclerosis   single-nuclei transcriptome   endolysosomal pathway   genetic mechanism  

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...

Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

Recurrent Pattern Completion Drives the Neocortical Representation of Sensory Inference

Information Science, Artificial Intelligence, Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
neocortex   pattern completion   sensory inference   illusory contours   visual cortex   neural coding  

Academic Background: Exploring Perceptual Inference and Neural Mechanisms In everyday life, our sensory systems often encounter incomplete or ambiguous information. For instance, when objects are occluded, the brain relies on prior experience and expectations to infer the whole. This inferential ability is not only a core function of the human visu...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aberrant splicing   C9orf72   repeat expansion   ALS   frontotemporal dementia   DPR proteins   therapeutic targets  

New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...

MASA-TCN: Multi-Anchor Space-Aware Temporal Convolutional Neural Networks for Continuous and Discrete EEG Emotion Recognition

Information Science, Computer Science, Artificial Intelligence, Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
EEG signals   emotion recognition   temporal convolutional neural network   space-aware   continuous regression   discrete classification   multi-anchor fusion  

A Breakthrough in EEG Emotion Recognition: The Proposal and Experimental Analysis of the MASA-TCN Unified Model Academic Background and Research Motivation Human emotion recognition has long been a popular research direction in neuroscience, artificial intelligence, and human-computer interaction. Automatic identification of individual emotional st...